Cellular processes are orchestrated by a large number of biomolecules in a spatially and temporally coordinated manner within a tiny volume. To uncover the underlying organizational principles and their functional relevance, we take microscopy visualization as the primary approach to systematically map the spatial localization, temporal dynamics and activity profiles of proteins and nucleic acids.
Our interests
Subcellular, high-resolution, and dynamic mapping of the entire proteome.
Physical organization and dynamics of the nucleus and the genome.
Subcellular compartmentalization of signaling molecules.
Our technologies
Super-resolution and light-sheet microscopes to visualize subcellular structures at a higher spatial resolution, record long term cell behavior, and track cells in intact animals.
New fluorescent probes and gene editing methods for labeling of endogenous proteins.
Computational imaging and machine learning techniques using data to see more clearly and do high throughput analysis.
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We’re hiring postdocs and graduate students
We particularly seek talents in optical engineering, machine learning, and cellular microscopy.
