Bo Huang          Curriculum vitae         Full Version

1700 4th St, MC 2532
Byers Hall 303A
San Francisco, CA 94143

Tel: (415) 476-1866
Fax: (415) 514-1028
Email:  

Employment

Professor, Department of Pharmaceutical Chemistry and Department of Biochemistry and Biophysics, UCSF 2017-
Associate Professor, Department of Pharmaceutical Chemistry and Department of Biochemistry and Biophysics, UCSF 2014-2017
Assistant Professor, Department of Pharmaceutical Chemistry and Department of Biochemistry and Biophysics, UCSF 2009-2014

Academic Training

Harvard University
    Postdoctoral Fellow                     Mentor: Xiaowei Zhuang
2006-2009
Stanford University
    Ph.D. in Chemistry                      Advisor: Richard N. Zare
    Thesis: Chemical analysis of single cells
2001-2006
Peking University, China
    B.S. in Chemistry summa cum laude
1997-2001

Honors Received

♦  UCSF Byers Award in Basic Science 2017
♦  Chan Zuckerberg Biohub Investigator 2017-2022
♦  ASCB Early Career Life Scientist Award 2016
♦  NIH Director's New Innovator Award 2011
♦  Packard Fellowship for Science and Engineering 2010
♦  Searle Scholars 2010
♦  GE & Science Young Life Scientist Prize
    North American Regional Winner
2007
♦  Annual Reviews Prize in Physical Chemistry,
    Stanford University
2006
♦  Stanford Graduate Fellowship 2001-2004
♦  Rado Young Genius Prize in China, First Place 1996

Selected Publications

  • 70. X. Shi, G. Garcia, J.C. Van De Weghe, R. McGorty, G.J. Pazour, D. Doherty, B. Huang*, J.F. Reiter*, "Super-resolution microscopy reveals that disruption of ciliary transition zone architecture is a cause of Joubert syndrome", Nat. Cell Biol. (2017).
  • 69. R. McGorty, D. Xie, B. Huang, "High-NA open-top selective-plane illumination microscopy for biological imaging", Opt. Express, 25, 17798-17810 (2017).
  • 68. S. Feng, S. Sekine, V. Pessino, H. Li, M.D. Leonetti, B. Huang, "Improved split fluorescent proteins for endogenous protein labeling", Nat. Commun., accepted (2017).
  • 63. J. Guan, H. Liu, X. Shi, S. Feng, B. Huang, "Tracking multiple genomic elements using correlative CRISPR imaging and sequential DNA FISH", Biophys. J., 112, 1077-1084 (2017).
  • 62. W.Q. Ong, Y.R. Citron, S. Sekine, B. Huang, "Live cell imaging of endogenous mRNA using RNA-based fluorescence "turn-on" probe", ACS Chem. Biol., 12, 200-205 (2017).
  • 56. M.D. Leonetti, S. Sekine, D. Kamiyama, J.S. Weissman, B. Huang, "A scalable strategy for high-throughput GFP tagging of endogenous human proteins", Proc. Nat. Acad. Sci. USA, 113, E3501-E3508 (2016).
  • 53. D. Kamiyama, S. Sekine, B. Barsi-Rhyne, J. Hu, B. Chen, L.A. Gilbert, H. Ishikawa, M.D. Leonetti, W.F. Marshall, J.S. Weissman, B. Huang, "Versatile protein tagging in cells with split fluorescent protein", Nat. Commun., 7, 11046 (2016).
  • 51. B. Chen, J. Hu, R. Almeida, H. Liu, S. Balakrishnan, C. Covill-Cooke, W.A. Lim, B. Huang, "Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci", Nucleic Acids Res. 44, e75 (2016).
  • 50. D. Kamiyama, R. McGorty, R. Kamiyama, M.D. Kim, A. Chiba, B. Huang, "Specification of dendritogenesis site in Drosophila aCC motoneuron by membrane-enrichment of Pak1 through Dscam1", Dev. Cell, 35, 93-106 (2015).
  • 47. R. McGorty, H. Liu, D. Kamiyama. Z. Dong, S. Guo, B. Huang, "Open-top selective plane illumination microscope for conventionally mounted specimens", Opt. Express, 23, 16142-16153 (2015).
  • 43. R. McGorty, J. Schnitzbauer, W. Zhang, B. Huang, “Correction of depth-dependent aberrations in 3D single molecule localization and super-resolution microscopy”, Opt. Lett., 39, 275-278 (2014).
  • 42. B. Chen, L.A. Gilbert, B.A. Cimini, J. Schnitzbauer, W. Zhang, G.W. Li, J. Park. E.H. Blackburn, J.S. Weissman, L.S. Qi, B. Huang, “Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system”, Cell, 155, 1479-1491 (2013).
  • 40. E.M. Puchner, J.M. Walter, R. Kasper, B. Huang*, W.A. Lim*, “Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory”, Proc. Nat. Acad. Soc. USA, 110, 16015-16020 (2013).
  • 36. R. Irannejad, J.C. Tomshine, J.R. Tomshine, M. Chevalier, J. Steyaert, S.G.F. Rasmussen, H. El-Samad, B. Huang, M. von Zastrow, “Conformational biosensors reveal adrenoceptor signaling from endosomes”, Nature, 495, 534-538 (2013).
  • 33. V. Mennella, B. Keszthelyi, K.L. McDonald, B.  Chhun, F. Kan, G.C. Rogers, B. Huang, D.A. Agard, “Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization”, Nat. Cell Biol., 14, 1159-1168 (2012).
  • 31. L. Zhu, W. Zhang, D. Elnatan, B. Huang, “Faster STORM with compressed sensing”, Nat. Methods, 9, 721-723 (2012).

Professional Activities

  • Instructor, 2010 Bangalore Microscopy Course
  • Instructor, 2011, 2013, 2016, 2017 Cold Spring Harbor Laboratory Course in Quantitative Imaging
  • Co-organizer, 2012-2014 QB3-UCSF Course on Biological Microscopy
  • Member, Biophysical Society (2002-Date)
  • Member, American Chemistry Society (2005-Date)
  • Member, American Society of Cell Biology (2008-Date)
  • Journal Reviewer: Cell, Nature, Science, Nature Methods, Nature Biotechnology, Nature Cell Biology, Nature Communications, PNAS, eLife, Developmental Cell, Journal of American Chemical Society, Structure, Nano Letter, Nanoscale, Journal of Molecular Biology, Biophysical Journal, Optica, Optics Letter, Optics Express, Biomedical Optics Express, Microscopy Research and Technique, PLoS One, Scientific Report, etc.