Watching the inner life of a cell
      

Cellular processes are orchestrated by a large number of biomolecules in a spatially and temporally coordinated manner within a tiny volume. To uncover the underlying organizational principles and their functional relevance, we take microscopy visualization as the primary approach to systematically map the spatial localization, temporal dynamics and activity profiles of proteins and nucleic acids.

 

We are particularly interested in the following problems:
 

In order to study these systems, we are developing the following microscopy technologies:
 

 

Research updates

High-NA open-top SPIM
(Opt Express 2017)
New mNG2_11 & sfCherry2_11 tags
(Nat Commun 2017)
SpyTag
for STORM
(ChemBioChem 2017)

Lab updates...