Watching the inner life of a cell
      

Cellular processes are orchestrated by a large number of biomolecules in a spatially and temporally coordinated manner within a tiny volume. To uncover the underlying organizational principles and their functional relevance, we take microscopy visualization as the primary approach to systematically map the spatial localization, temporal dynamics and activity profiles of proteins and nucleic acids.

 

We are particularly interested in the following problems:
 

In order to study these systems, we are developing the following microscopy technologies:
 

 

Research updates

High-throughput
zebrafish screening
(PLoS One 2016)
Creating a GFP
knock-in library
(PNAS 2016)
Protein labeling
using FP11 tags
(Nat. Commun. 2016)

Lab updates...