Watching the inner life of a cell
      

Cellular processes are orchestrated by a large number of biomolecules in a spatially and temporally coordinated manner within a tiny volume. To uncover the underlying organizational principles and their functional relevance, we take microscopy visualization as the primary approach to systematically map the spatial localization, temporal dynamics and activity profiles of proteins and nucleic acids.

 

We are particularly interested in the following problems:
 

In order to study these systems, we are developing the following microscopy technologies:
 

 

Research updates

SpyTag
for STORM
(ChemBioChem 2017)
HER clustering
resolved by STORM
(PNAS 2017)
Multiplexed tracking by CRISPR imaging + FISH
(Biophysic J 2017)

Lab updates...