Watchings the inner life of a cell
Cellular processes are often carried out by coordinated participation of many proteins. To understand how them work together, we are developing super-resolution microscopy and single-molecule imaging methods and using them to study the following problems:
(1) proteins organization in large complexes such as the nuclear pore complex and centrosome,
(2) dynamic protein interaction in regulating G-protein coupled receptor signaling,
(3) cell adhesion molecules in controlling the development of the nervous system, and
(4) protein-DNA interactions in the nucleus.
We are also interested in combining synthetic chemistry, protein engineering and microfluidics-based high-throughput screening to create new fluorescent probes that allow us to better study these cellular structures and processes.
- A simple way to stabilize the microscope stage in three dimensions (Optical Nanoscopy 2013)
- Rose and Harrison both won the NSF Graduate Research Fellowship!
- Nanobodies tell the activation of G-protein coupled receptors in living cells (Nature 2013).